idbeholdME: A Diablo series doesn't have to necessarily follow the plot of the games. We could get stories from anywhere from Sanctuary. Ivgorod, Xiansai, Bramwell, Duncraig, Kingsport, Skovos etc.
Or it could be about the history of Sanctuary, retell the story of Uldyssian or even Inarius and Lilith.
And if it was made in the style of D3 cinematics, but made into a series, I would be in heaven.
Those are valid points. After all, Castlevania has become a success. It all depends on the story, as you indicate, and with Netflix all of a sudden having become something of an animation powerhouse, who knows. It could turn out good.